#1 - Venice
There is nothing like Venezia. It's a sinking city that has perfect weather and less crowds from October to April. The Grand Ball is at Carnevale is an event everyone should attend once. It is a magical place.
Honorable Mention: Rome
#2 - Paris
No other city has food, art, and culture down like Paris. The City of Lights is great by day and better by night. The best arrondissements to visit are the 1st, 3rd, and 7th. Paris, France is simply fantastic.
Honorable Mention: Bordeaux
#3 - New York City
They say New York is the City that never sleeps. It's true, if you want to get food at 3 or 4AM and sit down it can happen. You might also catch last call. NYC is one of the best world cities on the planet.
Honorable Mention: San Francisco
#4 - Los Angeles
The City of Angeles is doesn't miss a beat. Head west and walk the Santa Monica Pier, stroll Beverly Hills, then catch some late night tunes in Hollywood. There is always something to do.
Honorable Mention: San Diego
#5 - Berlin
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Honorable Mention: Vienna
#6 - London
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Honorable Mention: Belfast
#7 - Amsterdam
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Honorable Mention: Las Vegas
#8 - Florence
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Honorable Mention: Verona,
#9 - Tokyo
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Honorable Mention: Siem Reap
#10 - Hong Kong
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Honorable Mention: Beijing